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文献摘要:虾青素和叶黄素与过氧亚硝酸盐的反应产物——硝化虾青素和硝化叶黄素及它们的抗氧化、抗肿瘤及抗癌变作用
发布时间:2017-03-14 14:49:14  阅读次数:702

          虾青素通过捕获过氧亚硝酸盐形成硝化虾青素。 15-硝化虾青素是虾青素与过氧亚硝酸盐反应的一个主要产物。本文研究了15-硝化虾青素的抗氧化、抗肿瘤及抗癌变作用。与虾青素相比较而言,15-硝化虾青素具有良好的单线态氧猝灭活性。此外,15-硝化虾青素可以抑制人类疱疹病毒早期抗体的产生及二期小鼠乳头瘤细胞的产生,这些活性都比虾青素高。叶黄素和过氧亚硝酸盐反应的产物15-硝化叶黄素也有类似的结果。

 

Anti-oxidative, anti-tumor-promoting, and anti-carcinogensis activities of nitroastaxanthin and nitrolutein, the reaction products of astaxanthin and lutein with peroxynitrite.

 

Astaxanthin captured peroxynitrite to form nitroastaxanthins. 15-Nitroastaxanthin was a major reaction product of astaxanthin with peroxynitrite. Here, the anti-oxidative, anti-tumor-promoting, and anti-carcinogensis activities of 15-nitroastaxanthin were investigated. In addition to astaxanthin, 15-nitroastaxanthin showed excellent singlet oxygen quenching activity. Furthermore, 15-nitroastaxanthin showed inhibitory effects of in vitro Epstein-Barr virus early antigen activation and two-stage carcinogensis on mouse skin papillomas. These activities were slightly higher than those of astaxanthin. Similar results were obtained for the 15-nitrolutein, a major reaction product of lutein with peroxynitrite.

 

Marines Drugs. 2012, 10(6):1391-1399.
Maoka T,Tokuda H, Suzuki N, Kato H, Etoh H.


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