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对紫外引起的皮肤损伤的局部保护作用
发布时间:2017-08-18 15:27:57  来源:文献摘要:难溶性抗氧化剂虾青素脂质体制剂  阅读次数:445

 虾青素被认为是生物膜上高效的抗氧化类胡萝卜素,可以防止紫外线对皮肤的损坏。但是,由于它水溶性很差,因此很难将其应用到皮肤上。在本研究中我们试图通过脂质体包含虾青素达到在水相中分散的程度,从而使其能够应用到皮肤上。虾青素脂质体在水相中对化学发光依赖性单线态氧具有强大的清除能力。在紫外线照射前施加虾青素脂质体可以预防紫外线诱导的皮肤增厚。有趣的是,事前添加虾青素脂质体可以阻止紫外线导致的胶原蛋白减少。此外,局部添加阳离子脂质体所形成的虾青素脂质体可以抑制紫外线照射皮肤产生的黑色素。因此,我们使用部分包含虾青素的脂质体制剂成功的阻止了紫外线导致的皮肤损伤。

 

Protective effects of topical application of a poorly soluble antioxidant astaxanthin liposomal formulation on ultraviolet-induced skin damage.

 

Astaxanthin (Asx) would be expected to prevent ultraviolet (UV)-induced skin damage, as it is regarded as a potent antioxidative carotenoid in biological membranes. However, it is difficult to administer Asx topically to skin because of its poor water solubility. In this study, we attempted to solve this problem by preparing liposomes containing Asx (Asx-lipo), which were dispersible in the water phase, and therefore, suitable for topical application to the skin. Asx-lipo was shown to have potent scavenging ability against chemiluminescence-dependent singlet oxygen production in the water phase. When Asx-lipo was applied to skin before UV exposure, UV-induced skin thickening was prevented. Interestingly, collagen reduction induced by UV exposure was also prevented by preadministration of Asx-lipo. In addition, topical administration of Asx-lipo containing cationic lipid inhibited melanin production in skin exposed to UV. Consequently, we succeeded in preventing UV-induced skin damage using a topical application of a liposomal formulation containing Asx.

作者与资料来源:Hama S, Takahashi K, Inai Y, Shiota K, Sakamoto R, Yamada A, Tsuchiya H,Kanamura K, Yamashita E, Kogure K.  Journal of pharmaceutical sciences 2012101(8):2909-2916.



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